Anti-PDX1 Polyclonal Antibody
應(yīng)用 WB IHC
稀釋比例WB 1:2000-5000.IHC 1:50-200.
交叉反應(yīng)Human Mouse Rat

產(chǎn)品型號：K106453P

更新時間：2022-08-15

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Anti-PDX1 Polyclonal Antibody

英文名稱	Anti-PDX1 Polyclonal Antibody
宿主	Rabbit
別名	GSF;IDX-1;IPF1;IUF1;MODY4;PAGEN1;PDX-1;STF-1
應(yīng)用	WB IHC
稀釋比例	WB 1:2000-5000.IHC 1:50-200.
交叉反應(yīng)	Human Mouse Rat
蛋白分子量	48kDa
Gene ID	3651
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	A synthetic peptide of human PDX1
性狀	液體
Public Immunogen Range	A synthetic peptide of human PDX1
Subcellular Locations	Cytoplasm Nucleus cytosol
Swiss Prot	P52945
克隆類型	Polyclonal Antibody
背景資料	Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.