Anti-MADH7 Polyclonal Antibody
應(yīng)用 IHC
稀釋比例IHC 1:50-200.
交叉反應(yīng)Human

產(chǎn)品型號：K106646P

更新時間：2022-08-15

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Anti-MADH7 Polyclonal Antibody

英文名稱	Anti-MADH7 Polyclonal Antibody
宿主	Rabbit
別名	CRCS3;MADH7;MADH8;Hsmad7；MAD homolog 8
應(yīng)用	IHC
稀釋比例	IHC 1:50-200.
交叉反應(yīng)	Human
蛋白分子量	46kDa
Gene ID	4092
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	A synthetic peptide of human MADH7
性狀	液體
Public Immunogen Range	A synthetic peptide of human MADH7
Subcellular Locations	Nucleus
Swiss Prot	O15105
克隆類型	Polyclonal Antibody
背景資料	Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R1-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.